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The developmental stage, distribution and functions of DMD gene products in the CNS, although not well characterised, are believed to be different for each isoform.
There is already evidence that both ARAF and CRAF affect pathways other than MEK, and although not well characterised, it is possible that other BRAF targets may exist (Wellbrock et al, 2004a).
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The pathogenesis of CD is not well characterised, although environmental, genetic and microbial factors leading to a dysregulated immune response are all thought to play key roles.
Although their exact molecular function is not well characterised, they can act as homotypic adhesion proteins in cell culture [8] and at least in some contexts their intracellular domains are dispensable [9], [10], supporting the idea that their primary roles are in cell adhesion.
Although the ligands for γδ T cells are not well characterised, γδ T cells may also be selected on cognate self-peptide 1.
This may be due to malformed structural changes during development, although its exact cause and incidence are still not well characterised (for review, see [ 71]).
Similarly, most of the 24 loci analysed in the present study are suggested to include genes with hypothalamic expression, although the specific molecular mechanisms behind these links are not well characterised [28].
The clinical and dimensional features associated with suicidal behaviour in bipolar patients during euthymic states are not well characterised.
Although chemokine receptors have been well characterised in humans, the chemokine receptor repertoire of cattle is not well characterised and many sequences are yet to be experimentally validated.
Although TNF-R2 has been shown to mediate signals that promote tissue repair and angiogenesis, the functional consequences of TNF-R2 signalling are not well characterised.
The role of SVEP1 is not well characterised.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com