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It was initially introduced in 1948 as a pesticide against rats and mice, and is still used for this purpose, although more potent poisons such as brodifacoum have since been developed.
These studies highlight the possibility that nucleoside analogues could potentially be developed for flavivirus therapy although more potent compounds with reduced toxic effects on the host cells will need to be generated.
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In literature, muscarine chloride has been reported to have similar activity as acetyl choline, such as reducing BP and HR; although being more potent [ 36].
Its neutralization capacity is similar to that of b12, although b12 is more potent and both antibodies neutralize a different spectrum of viruses [35].
All LPS serotypes tested (O157 H7, O103 H2, O111 HN, O121 H19 or O111 B4) induced increased aggregate formation, although O157 H7LPS was more potent compared to the other serotypes (Figure 2C and 2D).
In contrast, although Ub0 is more potent than CsA at PTP inhibition in liver and skeletal muscle mitochondria [27], Ub0 was ineffective in preventing PTP opening-induced cell death in HL 60 cells [26].
All three retinoids were also able to regulate to a similar extent both genes in purified primary Schwann cell cultures (Fig. 7B), although TTNPB was more potent, specially regarding RAR-β up-regulation, indicative of its higher affinity for RAR binding compared to the natural retinoids [32].
A similar pattern was evident for calcipotriol, although alfacalcidol was more potent in the assay.
Thus, although HIDEMs exhibited more potent activity with respect to inhibition of T cell proliferation, they did not differentially impact T cell activation.
There were also no great differences in the RAP values determined, although methyltrienolone was more potent in the lacZ-based bioassay.
Interestingly, although SB203580 was more potent than KN62 at inhibiting anti-IgM-specific gene expression, both compounds were - nonetheless - similarly effective at inhibiting the cell cycle arrest response.
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