In the present study, we investigated the biological safety of platinum nanoparticles in mice and found that platinum particles of less than 1 nm induced kidney injury, although the injurious effects were reduced by increasing the nanoparticle size.
Although the injurious effects on survival attenuate after adjustment for age, weight loss at diagnosis, tumor stage, radicality of surgery, smoking status, and gender, alcohol drinking remains an important and independent predictor of unfavorable outcome.
Although this action was injurious to Mepkin's bottom line in the short run, in the long run it was beneficial.
That VT setting provided a clear distinction from the injurious model, although it exceeded the current clinical recommendation for VT of 6 ml/kg of predicted body weight in ARDS patients [ 38, 39] and even lower settings (4.2 ml/kg) for ARDS patients with high Pplat [ 40].
However, although the initial inciting event (mechanical ventilation) may be injurious, interaction between the innate immune system and mechanical injury may be required for the development of the full-blown lung injury phenotype of VILI.
IPF is now thought to result from wound-healing processes that, although initiated to protect the host from injurious environmental stimuli, lead to pathological fibrosis due to these processes becoming aberrant or over-exuberant.
Although many of the secondary processes can be injurious, they appear to be primarily epiphenomena of the 'execution' phase of cell death.
Although essential for tissue survival, oxygen can be injurious during reperfusion.
42 43 Accordingly, the mere fact that medical care was sought does not necessarily imply that an injury was more severe, although this is probably less true when different categories of injurious falls are examined within the same population.
Although we tried to reduce heterogeneity in the definitions of injurious falls as much as possible by grouping them in more homogeneous categories, remaining inconsistency in definitions may also help explain the heterogeneity observed between studies.
