Although QbR was initially introduced for drug products submitted in ANDAs, its principles apply equally well to drug products submitted in NDAs.
Although it was initially introduced for signal denoising, the concept of nonstationary filtering can be used to retrieve the signal with specific characteristics from the time-frequency domain.
Google Gears was initially introduced for general Web browsing.
The idea that interatomic distances or bond lengths interpreted in terms of covalent radii was initially introduced for carbon.
Although most commonly used to measure H-H cross relaxation rates between protons within 5 6 Å (in this case referred to as the NOESY experiment), this approach was initially introduced for measuring chemical exchange processes near the slow limit of exchange [ 52].
Many of the current drugs used in ICU sedation were initially introduced for general anesthesia or short-term sedation during regional anesthesia.
Although initially introduced as a "temporary measure", more than 30 years later this barbaric experiment in social engineering is, astonishingly, still in force.
Although arthroscopy of upper extremity joints was initially introduced mainly for diagnostic purposes it is being increasingly used for therapeutic interventions [ 1].
Time series models have been initially introduced either for descriptive purposes like prediction or dynamic control.
When initially introduced, thrombolysis for acute myocardial infarction was restricted to specialist centres and under the guidance of cardiologists.
