Indeed, although common in trials examining glycemic control, no other treat-to-target statin trials are expected in the near future.
Bias is unlikely to be a major issue as this is a randomised trial, although in smaller trials important random variations between arms can occur.
The risk ratio assigned to the primary outcome of death or disability in the three major trials was very similar, although in two trials the 95% confidence intervals crossed unity.
Although differences in trial designs and definitions should be considered when interpreting the overall results, mortality is a hard end point not affected by study definitions.
Although Indonesia is awash in trials and investigations these days, protesters have channeled their passions into the Suharto case.
On the other hand, one may say that the negative trials on SGC did not show that mild hyperglycemia harmed ICU patients (although in most trials hyperglycemia was less severe than in the two positive RCTs).
However, although in vaccination trials a good response was seen, the vaccine was less successful in field conditions [ 4].
The foxtail millet parent was more variable in flowering time compared to the RILs, although in most trials it was among the latest to flower.
Although in most trials, consent to random allocation is sought before the allocation takes place, there are some acceptable exceptions when randomisation is carried out prior to consent (Zelen randomisation), as in this trial (see Ethics, below).
Oral bisphosphonates have been associated with gastrointestinal intolerance in some clinical practice patients, although in clinical trials there have been no significant differences in gastrointestinal adverse events in bisphosphonate-treated patients versus those on placebo.
