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Although in this trial most patients received moderate cisplatin doses, only one had grade 3 peripheral neuropathy.
Similar results were earlier reported by the smaller 'Ferric Iron Sucrose in Heart Failure' (FERRIC-HF) trial testing i.v. iron sucrose for 16 weeks, although in this trial the benefits were more pronounced in anaemic patients.
Although in this trial efficacy was similar in both arms in terms of progression-free survival, overall survival, and response rate, this trial failed to show benefits in terms of less toxicity for the nonplatinum-based regimen.
Similar(57)
Although patients in this trial were asymptomatic, this should not be considered a primary prevention study because subjects had some degree of peripheral arterial disease (PAD).
Although women in this trial were volunteers, the prevalence of incontinence in this sample was similar to that in other population-based studies among women with diabetes (19) and higher than among women without diabetes (5).
Although ORR in this trial was not different between the bevacizumab and the placebo arms, potentially curative surgery was performed in 55 (9.6%) patients on bevacizumab vs. 38 (6.6%) on placebo (p=0.061) in the per protocol population.
Although both individuals in this trial were still incarcerated in the facility and therefore able to receive their confirmatory results a week later, there will be cases of release prior to receipt of results.
Although, 75 women in this trial opted to use NRT, this design makes it difficult to disentangle any effect of NRT from that of intensive behavioural support.
Although the therapy in this trial was well tolerated without signs of toxicity, and some of the patients demonstrated measurable increases in circulating Factor VIII levels, all patients failed to maintain detectable expression beyond 10 months.
Finally, although the attrition in this trial was approximately 30% at 6 months and nearly 40% at 12 months, significantly more CBT users than control group participants withdrew from the study, possibly reflecting the study burden.
3, 11, 13 The year of accrual also influenced the identification rate and reflected a learning curve, although surgeons participating in this trial were past their learning period of 30 SNB procedures with a completion axillary clearance.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com