Although in-silico functional profiling of gene expression data and miR-125a target genes lends some support to the idea that miR-125a over-expression is linked to the hyperglycaemic phenotype, further evidence from other model systems or functional studies is certainly desirable.
Hippocampal volume declines are less apparent during normal ageing, although declines in functional activations of the hippocampus and surrounding cortex have been observed in healthy older adults.
Although observed, improvements in functional outcome were not quantified.
Although recent advances in functional genomics provide a deeper understanding of hepatocarcinogenesis [ 3, 4], the molecular pathogenesis of HCC remains rather unclear.
Although the decline in functional performance was particularly high among persons aged 80 years and older, the changes in functional ability were not related to age or gender among people aged 70 years and older.
Although the emphasis in functional imaging studies of PD is on dopamine neurotransmission, it is noteworthy that PD is also associated with grey matter atrophy of the lateral prefrontal cortex (Burton et al. 2004; Rowe, Hughes, Williams-Gray et al. 2010) and changes in its underlying white matter (Rae et al. 2011).
However, in Drosophila slo-1 mutants remain sensitive to the acute actions of ethanol although they are defective in functional tolerance [25], [26].
Bioinformatics is one important tool in functional genomics, although showing clear limitations in predicting ab initio gene structures, gene function and protein folds from raw sequence data.
We report that nucleolar dominance is a process where NORs of both parental species are modified in the wheat-rye combination (although in opposite functional directions), in contrary to the differential amphiplasty concept as described by Navashin in 1930s [19] affecting only under-dominant NORs.
Although in vivo functional recovery by means of OEC transplantation has been reported by several groups, the mechanism of the regeneration-promoting ability is still far from clear.
