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Although extensive progress has been made in the understanding of sperm chromatin packaging into protamine toroids [ 17], genome-wide histone retentions [ 10, 11, 19] and DNA methylation [ 20] epigenetic factors of infertility and their effect on embryogenesis still remain to be elucidated.
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Unfortunately, the data about these questions are still insufficient, although remarkable progress has been achieved.
Although some progress has been made, there is still a long way to go.
Although encouraging progress has been made, the results are still far from satisfactory.
Although noticeable progress has been made, the rate of recovery of transgenic lines is still low.
Although significant progress has been made, we will not achieve the target.
Although significant progress has been made during the last years in analysing the signals regulating endochondral ossification in the developing embryo, complete understanding of the control system in adult cells and tissues will require further extensive studies.
Although considerable progress has been made in recent years, we have a long way to go.
Although some progress has been made in past years, suitable drugs are still lacking.
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