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These data demonstrate that the CXCR4 tail, although dispensable for G-protein association, is required for heterotrimeric G-protein activation.
Although dispensable in the first stage of human Th17 differentiation, IL-23 is required to drive terminal differentiation and maintenance of already committed Th17 cells [21].
Although dispensable in our experimental growth conditions, complete polysaccharides are likely to be essential on more realistic environments.
These results suggest that tap function, although dispensable for fertility in Drosophila, is required for transposon repression in germline cells.
Our results in the present study show that – although dispensable for completion of meiosis – pheromone control extends beyond the point of meiotic entry.
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ACIAD1374 (ispU, undecaprenyl pyrophosphate synthetase), involved in its synthesis, was observed essential, although predicted dispensable (see Figure 8B).
Specifically, RhoE is essential for myoblast elongation and alignment before fusion, although it is dispensable for myogenesis induction [23].
Although annotated as dispensable in the Stanford Yeast Genome Database (http://www.yeastgenome.org/cgi-bin/locus.fpl?locus=kre28), we find KRE28 to be essential for vegetative growth.
Although Rac1 appears dispensable to normal in vivo angiogenesis, the question remained as to whether elevated Rac1-activity could influence angiogenesis.
IL-5 is the most important factor that regulates the expansion, growth and survival of eosinophils although it is dispensable for eosinophil development under homeostatic conditions [4].
Although Securin is dispensable for mammalian cells and mouse [28], [42] [45], inhibitory phosphorylation provides an additional layer of regulation in vertebrates [24], [25].
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