Both 1A5 and 2C5 possessed potent neutralizing activities, although they directed against distinct conformation-dependant epitopes as shown by ELISA and binding competition assay.
First, we cannot formally exclude that the humoral response does not control expansion of infected cells although antibodies directed against the gp51 viral envelope protein remain constant upon splenectomy.
Therefore, both proteins are considered key targets for vaccination and are included in all types of influenza vaccines (although antibodies directed against NA are not considered neutralization antibodies).
Congress responded by passing the Radio Act of 1927, which, although directed primarily against monopoly, also set up the agency that is now called the Federal Communications Commission (FCC) to allocate wavelengths to broadcasters.
Although drug combinations directed against two or more targets are widely employed in treatment of some diseases, the polypharmacology of marketed drugs or of new molecular entities is the new emerging paradigm for the targeting multifactorial complex diseases.
The purified antibody resulted in a loss of neuronal GFAP+1 signal, although other antibodies directed against the amino- and carboxy-terminus of GFAPα still revealed GFAP-immunopositive neurons, as described before.
Although active immunotherapy directed against specific target molecules expressed in cancer offers promise for cancer treatment, a considerable amount of research needs to be carried out before it can be considered a viable therapeutic option.
Although inhibitory antibodies directed against β1-integrin (notably clone AIIB2) have already been shown to be effective in reverting the tumorigenic phenotype of breast cancer cell lines [ 64, 65], strategies to target the β1-integrin subunit for therapy (Table 1) have not progressed rapidly, presumably because of the heterogeneity of the β1 subgroup of integrins.
Although this criticism is directed against a cosmological argument, similar to that of Samuel Clarke in his first Boyle Lecture, it has been applied to ontological arguments as well.
The reply counter-protested that nine Japanese hospital ships had been attacked by the Allies, although these claims were directed against the United States, not Australia.
