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Although deficiency diseases have been described in laboratory animals and humans deprived of single vitamins, in human experience multiple deficiencies are usually present simultaneously.
Although deficiency of another major drug metabolizing enzyme activity (N-acetyltransferase) was demonstrated to result from the absence of detectable NAT genes in multiple species of Canidae [20], the mechanism for the loss of gene function is unknown, as is the timing of the loss with respect to canid evolution.
Although deficiency or defects of Treg cells cause severe inflammation and autoimmunity in vivo, recent studies have even shown that Tregs may have pro-inflammatory properties in certain scenarios, for example, by producing IL-17 [25] or by coordinating protective response against HSV-2 infection [37].
Although deficiency of MeCP2 function is the major cause of classical RTT, the exact pathological mechanisms have been elusive.
Although deficiency mapping proved problematic for RE-A (fat2), this method easily identified the gene corresponding to our second largest complementation group, RE-B.
Although deficiency of the receptor protects against acquisition of HIV, evidence is accumulating to suggest it plays a role in severity of illness caused by flavivirus infections (7, 8 ).
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This can push aside vitamin-rich natural foods, although deficiencies are regularly encountered.
Although deficiencies in these pathways did only partly deplete stem cell reserves with age, stem cell functional capacities were severely affected under conditions of stress, leading to loss of reconstitution and proliferative potential, diminished self-renewal, increased apoptosis and, ultimately, functional exhaustion [12], [13].
MCCR data quality varied with age, site and district - inviting action - and apparently compares favourably with elsewhere, although deficiencies in published data hampered definitive assessment.
Although deficiencies in copper-dependent proteins culminate in meiotic cell developmental defects and subfertility,, copper homeostasis has been poorly studied during meiosis.
Although deficiencies in NKT cells have been shown to be genetically linked or to precede the development of autoimmunity in murine models of autoimmune disease, data addressing these issues in humans are sparse.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com