As the monocots diverged, our data suggest that the components of the anthocyanin production pathway, although conserved functionally, began to show greater evidence of amino acid divergence.
Finally, the replacement of the octahydro-1,4-benzoxazine moiety of lead compound D with its respective 1,4-benzothiazine (compound 4), although conserved (anti-hypercholesterolemic) or even improved (anti-hyperlipidemic) activity, did not preserve the anti-diabetic effect of D.
The predicted structures of DmtA homologues, although conserved, are not identical.
Although conserved in the other Drosophila (Figure S6), no SecS homolog was found in the D. willistoni genome.
In addition, the X. laevis genome sequence is not available, and orthologous germ cell promoters from frogs and mammals, although conserved in terms of expression patterns, may diverge at the sequence level.
Similarly, although conserved sequences have been shown to correspond to true regulatory sequences, there are other known regulatory sequences that are not well-conserved, even within functional binding sites, or whose conservation levels are similar to those of other non-coding sequences [20] [21].
Although conserved regulatory gene expression patterns are suggestive of a functional role, such data is only correlative.
The other two ring-type residues, H247 and H252, although conserved among mammals, were not present in frog BTG3.
Although conserved miRNAs families are present in all plant families, some of the isoforms might play a specific role with their expression being unique to that particular tissue of the species [ 17, 31- 34].
The best characterized of these motifs is the RXLR motif found in the oomycete Phytophthora infestans [ 49], although conserved RXLR motif effectors have yet to be observed in fungi.
