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Interestingly, the TO prodrug Race although administered at a ten times higher dose than TO induced half as high an increase in the tumor uptake of [111In-DOTA]MG11 (6.81 ± 2.79 %ID/g, P < 0.001).
Prophylactic treatment, although administered in neutropenic patients, has not found its place in the critical care setting.
Although administered by injection, active drug metabolites were found in dust and aerosol of the stable and also ESBL-carrying E. coli were detected in the aerosol.
In contrast, G-CSF although administered intraperitoneally did not stimulate the local recruitment of neutrophils into the peritoneum, but rather acted systemically to stimulate neutrophil mobilization.
Although administered more frequently to in-patients, AA were not prescribed predominantly to severely ill patients contrary to evidence-based recommendations.
Finally, a low-dose, modified night-release formulation of prednisone, although administered in the evening (replacement therapy), has been developed to counteract the circadian (night) rise in proinflammatory cytokine levels that contributes to disease activity, and might represent the way to further optimize the DMARD activity exerted by GCs in RA.
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The 2005 ATS guidelines on hospital-acquired pneumonia concluded that although administering antibiotics at the time of intubation may prevent EO-VAP, its routine use could not be recommended until more evidence was available [39].
However, AZD0530 significantly decreased spheroid formation efficiency and average spheroid size in ULAS cultures, although administering AZD0530 did not alter the size or weight of mice following SKOV3 xenograft (data not shown).
Although administering appropriate antibiotics as well as antitoxin is a standard of care for patients with diphtheria, antitoxin was not given to this patient because of her rapid response to the erythromycin therapy.
From the perspective of the current hypothesis, these represent increased opportunities for paracetamol exposure in pain management (although administering several vaccines at once means analgesia may not increase proportionally).
Finally, although administering the DAP test can be done relatively quickly as stated in the manual in 10 to 20 min, we would prefer that the DAP test is used in multidisciplinary settings in collaboration with a psychologist.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com