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The phrase "although a major proportion" is correct and usable in written English.
It can be used to introduce a contrasting idea or exception regarding a significant part of a whole.
Example: "Although a major proportion of the population supports the new policy, there are still many who oppose it."
Alternatives: "even though a large percentage" or "despite a significant portion".
Exact(2)
Although a major proportion of children were found dead during sleep, a significant number were described as being awake at time of death (32%).
Although a major proportion of gene expression data have been collected for binary outcomes (e.g. normal vs. abnormal), data with other types of responses (e.g. survival data) have also been collected.
Similar(58)
Although chloramphenicol is now rarely used in human therapy, a major proportion of the screened isolates exhibited chloramphenicol resistance.
In some states, fentanyl makes up a major proportion of escalating opioid death tolls.
A major proportion of the world's population will be located in cities by 2030.
A major proportion of the radioactivity is from potassium.
A major proportion of the total energy demand for buildings is electricity for lighting.
A major proportion of these competitions are based on handwriting recognition and other related tasks.
By 2050, the world's population will reach 9 billion people, with a major proportion living in urban areas.
A major proportion of the leaf carbohydrate is starch.
Generally, substrates are a major proportion of product costs.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com