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It must be considered that whenever the amendment significantly alters the study design or the potential risks to which patients are exposed, each patient will have to be informed and will have to put down in writing her/his intention to continue the study.
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Their exclusion may have altered the study's results if they were also more likely -- or less likely -- than the others to be taking hormones.
In the early 1950s, she and Dr. Stanley Cohen, a biochemist also at Washington University, isolated and described the chemical, known as nerve growth factor — and in the process altered the study of cell growth and development.
These variations did not alter the study case and the desired results.
Thus, by altering the study set-up within the HyperStudy domain, the finite element solver is repeatedly fed different sets of input parameter values.
However, although this kind of study may offer superior performance, it can still be plagued by important methodological limitations, which could significantly alter the study outcome.
The availability of hundreds of bacterial genome sequences has altered the study of bacterial pathogenesis, affecting both design of experiments and analysis of results.
Moreover, sensitivity analyses including AIDS defining endpoints that occurred in the first 30 days after study entry did not alter the study results (data not shown).
This did not substantially alter the study findings.
However, we feel any such effect would be modest and unlikely to alter the study outcomes.
In addition, misclassifications alter the study of patient outcomes associated with effective treatment.
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CEO of Professional Science Editing for Scientists @ prosciediting.com