Sentence examples for alters the functional from inspiring English sources

A key mechanism by which cancer alters the functional fate of T cells is related to altered nutrient availability and metabolic state in the tumor microenvironment.

Because one of the earliest retinal effects of diabetes is the dysregulation of blood flow, we asked whether diabetes alters the functional organization of the capillary/arteriolar complex, which is the operational unit that plays an important role in regulating local perfusion.

Thus, we can speculate that genetic deletion of COX-2 alters the functional interplay between AMPA and NMDA receptors, leading to the dampening of NMDA receptors and potentiation of AMPA receptors.

Thus, we show that IL-12 inhibits directly human NSCLC growth, and others [30] have demonstrated in mouse models that IL-12 alters the functional profile of tumor associated macrophages (TAM) by rapidly reducing production of IL-10, MCP-1/CCL2, migration inhibitory factor and TGF-β1, and increasing release of TNF, IL-15 and IL-18.

Alternatively, ubiquitination of Myc by Fbw7 not only affects protein turnover but also alters the functional properties of Myc.

Developmental timing alters the functional impact of pathway activation on cortical neuronal precursor cells (Hirabayashi and Gotoh, 2005).

There are two main types of reactions [8]: construction reactions, which create new carbon carbon bonds in the target's skeleton, and functionalization reactions, which alter the functional groups attached to the skeleton but do not alter the skeleton itself.

Such modifications could, through increased calcium binding potential or altering the functional C-terminal extension, also have impact on the biological function of the protein when localized in the particular compartments.

We identified 30 human-specific "fixed" amino acid substitutions/indels including two amino acid substitutions that potentially alter the functional roles of their genes as candidate sites responsible for human-specific brain function.

Were any one of these parts to be altered, the functional integrity of the whole would be destroyed.

Even something as fundamental as being left-handed can alter the functional organisation of the brain.