Sentence examples for alters the active from inspiring English sources

Furthermore, phosphorylation of the enzyme at Ser505 by mitogen-activated protein kinases (MAPKs) alters the active site conformation.

Recent structural studies have provided evidence that yeast Nat1 alters the active site of Ard1 mediating sequence specific acetylation patterns of substrates (Liszczak et al., 2013).

Interestingly, only the M4 TEAS- cis-2F-FPP complex exhibits a significant shift in the position of Y520, which additionally alters the active site surface features.

In all characterized RNRs, the binding of effector dATP alters the active site to select for pyrimidines over purines, whereas effectors dGTP and TTP select for substrates ADP and GDP, respectively.

In other mutagenesis analyses, HDX MS was used to show that mutation E208Q in the SescA translocase, a mutation that alters the active site, changes the global conformational state.

As noted above, aspirin acetylation of COX-2 not only inhibits prostanoid formation, but alters the active site of COX-2 and thereby permits conversion of AA into 15 R-HETE (hydroxyeicosatetraenoic acid) or EPA to 18-HEPE in vascular endothelial cells as examples.

Ubiquitination of caspase-3 reduces activity of caspase-3 by altering the active site while also targeting the enzyme for proteasomal degradation.

Molecular models of this mutated protein showed that this mutation does neither alter the active site of α-galactosidase A nor interfere with the enzyme catalytic activity, but it could alter the enzyme stability [ 21].

As with skeletal muscle, changes in length alter the active force by varying the degree of overlap of the thick myosin and thin actin filaments.

These structures reveal, in particular, that this first mutation does not alter the active site.

It was found that adding the Co(Ni) citrate to Co2Mo10/Al2O3 catalyst significantly altered the active phase morphology.