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F-actin plays a crucial role in composing the three-dimensional cytoskeleton and F-actin depolymerization alters fate choice of mesenchymal stem/stromal cells (MSCs).
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Our results suggest that the epigenetic drug Aza-dC alters fates of pluripotent stem cells by driving these cells toward differentiation and apoptosis.
"To alter fate, the Chinese feel they need to do things to acquire more luck".
Remember how no sudden development and no single injury seemed capable of altering fate?
The medics' theory was that the urgent need to "save a life" was different where one sensed no ability to alter fate.
She wants to teach them courage, tries to impress on them her former teacher's lesson that "we can alter fate," that "for us, as humans, there is choice".
This manifests as delayed neuronal commitment, but not as altered fate choice as the these cells are able to overcome this initial defect and recover normal numbers of neuron-like cells after a further week in culture.
We hypothesized that the increased sensitivity of the BMP/Smad signaling pathway in TDSCs (CI) might account for their higher non-tenogenic differentiation potential and hence altered fate.
The sensitization of the BMP/Smad pathway in TDSCs (CI) might account for their higher non-tenogenic differentiation potential and hence altered fate.
This study was our first step to understand the mechanisms of non-tenogenic differentiation and hence altered fate of TDSCs (CI).
Consistent with this previous finding [ 17], TDSCs isolated from the CI model (TDSCs (CI)) showed altered fate, with higher chondro-osteogenic differentiation potential but lower tenogenic marker expression compared to TDSCs isolated from the healthy animals (TDSCs (HT)) [ 18].
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