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The phrase "alternatives were significantly different" is correct and usable in written English.
It can be used in contexts where you are comparing different options or choices and highlighting that they are not the same in a meaningful way.
Example: "In the study, the results showed that the alternatives were significantly different in terms of effectiveness."
Alternatives: "options varied considerably" or "choices were markedly distinct."
Exact(2)
However, the scores between the alternatives were significantly different; which impacted the stakeholders' decision-making.
In the main-effects model (Model 1), all attribute level alternatives were significantly different from zero except for household coverage as an evaluation indicator for the RBF mechanism (relative to individual coverage as an evaluation indicator).
Similar(58)
The social economics of high-potential ventures and small-scale employment alternatives are significantly different.
Embryos carrying a null mutation in the elav gene [ elav mutants (Yao et al., 1993)] produced patterns of Ubx alternative splicing (AS) and alternative polyadenylation (APA) that were significantly different from those found in wild-type embryos (Fig. 1A-H), indicating that Drosophila ELAV is necessary for normal Ubx RNA processing within the embryonic CNS.
Overall mean ± standard error annual mean CO2 flux estimates for the three alternative calculation methods with all pairs were significantly different between WY1999 and 2008 May 11998 Aprilril 30, 2008).
Tests for whether there is a phylogenetic signal, λ, to gene expression patterns were significantly different than the alternative of no signal (i.e., Brownian motion model of character evolution) (Table 3).
However, their structural features were significantly different.
In the tropics, though, the results were significantly different.
Post-dependent and non-dependent rats were significantly different (**p<0.01).
Post-dependent and non-dependent rats were significantly different (*p<0.05).
The weights were significantly different.
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Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com