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Our results suggest that multiple targeting of both Bcl-2 and XIAP or, alternatively, of several IAP family members by the Smac-N7 peptide is a potent way to overcome resistance of RCC to apoptosis-triggering treatment modalities, and might be a new tool for molecular targeted therapy.
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Alternatively, neurotropism of several parasites such as Trypanosoma sp) have been demonstrated at least in human.
Alternatively, one of several downstream in-frame methionine-encoding codons might function as the true start codon.
Alternatively, a search of several transcription-factor-binding-site databases, using the consensus 10 bp surrounding the 129B6 polymorphism, identified other potential transcription factor-binding sites (Table 1).
Alternatively co-packaging of several mRNA species, only one of which carries specific localization signal, has been shown in at least two cases (Lange et al., 2008; Jambor et al., 2011).
TRIM5α and TRIMCyp are two of several alternatively spliced isoforms of the TRIM5 gene [8].
Phosphorylation mutant analysis will reveal whether there is indeed one key substrate that initiates centrosome maturation or, alternatively, Plk1-dependent phosphorylation of several proteins, acting in parallel or complementary pathways, is required for efficient centrosome maturation and accumulation of γTuRCs.
We determined that IPF/UIP patients have increased protein levels of several alternatively activated pro-fibrotic (M2) macrophage-associated proteins in the lung and monocytes from these patients show skewing towards an M2 macrophage phenotype.
A common RNA from this region is the source of several alternatively spliced E1A transcripts [ 16].
Alternatively, the simultaneous absence of several EC numbers that belong to a specific pathway would suggest that the entire pathway is absent from the species concerned.
Alternatively, the crystal structures of several orphan receptors such as HNF4 were found to have a phospholipid constitutively bound to a large ligand binding pocket [ 5, 6].
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