One with heating (fall, winter) and without heating (summer, spring), alternatively modifying the type of indoor protection of the window and the thermal inertia of the enclosure.
Alternatively, modifying the nuclear topology to branch one of the two F. trichopoda and one of the two F. craterostoma accessions with Chlamydodorae and with Cyathistipulae and Crassicostae accessions respectively, as in the chloroplast topology, produced significantly worse topologies than the unmodified nuclear topologies for the nuclear dataset.
The product of the Agouti gene has been reported to inhibit lipolysis in human adipocytes [35], and thus expression of the K14-agouti cassette could potentially inhibit lipolysis in the mammary gland, or alternatively modify lipid biosynthesis in mammary epithelial cells resulting in the described lactation defect.
Alternatively, modified bile levels in the host could lead to altered intracellular c-di-GMP of intestinal pathogens, leading to increased probability or severity of disease.
Indeed, PCNA can be alternatively modified on the very same residue by either SUMO, a single ubiquitin moiety or by a specific (lysine63-linked) poly-ubiquitin chain (Hoege et al, 2002).
Taking into consideration residues that can be alternatively modified the "conserved face" displays 28 possible modifications amongst 19 residues, while the "variable face" supports a total of 53 modifications.
We noted a second band that migrated slightly more slowly than the recombinant protein in the PNGase F treated cell extracts that may represent an alternatively modified form of Fam20a.
In the prostate cell lines a second band of a slightly smaller size is also clearly visible and this may represent an alternatively modified (phosphorylated/glycosylated) or spliced form of EphB4.
The S-SMase enzyme, secreted by macrophages and endothelial cells, is an alternatively modified form of the 75 kDa protein product of the asm gene [encoding ASMase (acid SMase)], which also produces the lysosomal form of ASMase [ 5].
Alternatively, one could omit this constraint and instead modify the decoding procedure to be usable with all possible permutations.
Strategies to identify new organisms and enzymes with desired biofuel-relevant capabilities or alternatively, genetically modifying model organisms for optimized productivity, will require improved annotations and mechanistic insights into functional cellular processes, including transcriptional regulation, post-translational protein modifications and clues into regulatory networks [ 2].
