One study demonstrated that the alternatively spliced minor form of mouse TDP-43, which is lacking the C-terminal portion, interacted with SMN (Wang et al, 2002).
Alternatively, the minor QTLs are in involved in response to environmental cues other than day length, such as temperature because the average temperature during the growing season was higher in 2005 than in 2007.
As such, the level of protection in these studies may underestimate the utility of the approach or, alternatively, provides only minor protection for human disease.
Both studies mainly considered internal cassette exons and reached similar conclusions, namely, that young exons tend to be alternatively spliced and minor.
Genome-wide, the sequence-based prediction method suggested that 33% of NAGNAGs are alternatively spliced, producing minor isoforms with at least 2% frequency.
Although our present biochemical analysis did not detect a RyR1 association with RTN1A (Figs. 2D and 3), we cannot exclude that both proteins may associate weakly/transiently, or alternatively, that only minor amounts of these proteins interact in specific neurons.
Alternatively, a small proportion of introns (≈1%) are processed by the minor spliceosome comprising U11, U12, U4atac/U6atac, and U5 snRNPs [ 4].
The principal minors (alternatively the Eigen values) of the elastic constant matrix should all be positive at ambient conditions.
The principal minors (alternatively the eigenvalues) of the elastic constant matrix should all be positive at ambient conditions.
Applying this prediction method to all NAGNAG cases in Arabidopsis, 14% are predicted to be alternatively spliced with a minor transcript frequency of at least 10%, 21% with ≥ 5%, and 33% with ≥ 2%, respectively.
