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Alternatively, low level activation of caspase-8 may contribute to aberrant cell growth, since activation of the extrinsic death pathway at levels which do not induce apoptosis can foster NF-κB signaling [38].
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Alternatively, low levels of tumour markers could be also found in the presence of neoplasias.
Alternatively, low levels of soluble VEGF may independently increase sprouting behavior [ 36].
Alternatively, low levels of genetic diversification between species may indicate that speciation processes of some Chinese Lepus species are not complete and there have been continuous gene flow among them.
Alternatively, low levels of germline expression from extrachromosomal arrays could be responsible for the rescue; low levels of maternally expressed lin-35 from the arrays results in substantial suppression of developmental phenotypes in lin-35; fzr-1 double mutants (Fay et al., 2002).
We used Kaplan-Meier survival curves to show differences in clinical outcome between patients with tumours that expressed high alternatively low levels of ITGB3 mRNA or protein, using cut-off values at 0.29 and 0.43 respectively, based on the detected relative expression levels.
Alternatively, low-level methylation may flag the presence of a cryptic change-causing gene dysregulation.
Alternatively, low-level resistance can emerge due to point mutations in the regulatory region of the inhA operon.
It is uncertain whether this group has resolved infection, with or without long-term immunity and protection from further exposure to HCV or, alternatively, low-level viral replication, where HCV RNA can only be detected within the liver.
Alternatively, low-level viremia of HIV variants with distinct resistance profiles might be present in the CNS during chronic infections that cannot be eliminated by current cART regimens supporting the concept of CNS compartmentalization of HIV species.
There has been resurgent interest in this particular group following the demonstration of intrahepatic negative strand HCV RNA, suggesting continued viral replication, 11 leading to the suggestion that such patients have occult or, alternatively, low-level HCV replication, 12 but the effect of immune responses on viral turnover is uncertain.
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