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Two extremes of these activation states are classically activated (M1) and alternatively activated (M2) macrophages.
To distinguish this new phenotype from their familiar "classically activated" counterparts, these macrophages were referred to as "alternatively activated".
The two opposite activation states are known as classically activated (M1) and alternatively activated (M2) macrophages [ 10, 11].
Macrophage activation status was assessed to determine whether they were classically or alternatively activated.
Alternatively activated, pro-angiogenic, wound healing macrophages.
We demonstrate here that Pneumocystis polarizes macrophages towards an alternatively activated macrophage-like phenotype.
Of note, adipogenesis coincided with an increased accumulation of alternatively activated M2 macrophages [5, 7].
Tumor-associated macrophages (TAMs) have properties consistent with alternatively activated macrophages [27].
Many tumor-infiltrating monocytes are alternatively activated by cytokines released by existing tumor cells [41].
The resolution stage of the FBR is dominated by alternatively activated macrophages.
Macrophages may for example be classically activated to trigger inflammation (M1), or alternatively activated which supports healing and vascularisation (M2).
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