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Besides the application of the standardised test methods, alternative test methods and endpoints for the assessment of ENMs are published.
Other tools for Green Toxicology, including the reduction of animal testing, alternative test methods, and read-across approaches are also discussed.
Regulatory rationales were also an additional driver of alternative test methods, particularly those that identified compounds with alerts for "cut-off" hazards, such as mutagenicity and endocrine disruption.
A literature review on alternative test methods such as behaviour, nutritional performance, indicator for oxygen stress, haematology, histology, genotoxicity, cytotoxicity, neurotoxicity, immunotoxicity, bioaccumulation and biodiversity was performed in the project and the following conclusions were drawn: 1.
The ultimate challenge for developing non-animal test methods for skin sensitization testing will be applying our mechanistic understanding of ACD to the design of predictive in vitro alternative test methods.
The ultimate challenge for developing non-animal test methods is applyied in the mechanistic understanding of contact allergy and ACD to the design of predictive in vitro alternative test methods.
Similar(23)
As an alternative test method, the distorted waveforms generated by the Electro-Magnetic Traccuratelyogram (EMTP) are aclassifiedclassified.
An alternative test method to determine water retainability of porous fine aggregates is developed.
We therefore used an alternative test method that was recently developed by the authors.
This paper provides recommendations for how best to conduct the test, and proposes an alternative test method to that given in the EN 15512 Specification.
The newly revised Australian Standard AS 4084 adopted the European approach but also introduced an alternative test method for determining the combined bending and shear stiffness of upright frames in the transverse direction.
Related(19)
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