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Exons 71 74 undergo complex alternative splicing (omission of exon 71, of exon 74 and of exons 71 74) in humans and mice [ 27- 29].
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Two or more mature mRNAs are produced from a single precursor pre-mRNA by the inclusion and omission of different segments in a process called "alternative splicing" [ 139, 140].
We close this section by mentioning the highlights talk given by Mark Ragan (The University of Queensland), who reported an analysis of human transcriptomic data to elucidate the effect that alternative splicing has on the protein-protein interaction network, via inclusion or omission of certain interaction domains [ 36].
Alternative splicing of exons 2 and/or 3 leads to the inclusion or omission of sequences important for HBP/SLBP localization and stability, and for the HBP/SLBP function in histone mRNA metabolism such as its role in histone mRNA translation [ 12, 13, 22, 23, 34].
The omission of one of the five rod opsin gene exons by alternative splicing could account for the lack of immunoreactivity with both rod opsin antibodies.
In terms of alternative splicing, the Splicing Index algorithm was used to select alternatively spliced genes.
Kornblihtt, A.R. Promoter usage and alternative splicing.
Gassmann, W. Alternative splicing in plant defense.
S.X.T. performed experiments related to alternative splicing.
The ribosome-engaged landscape of alternative splicing.
Venables, J.P. Aberrant and alternative splicing in cancer.
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