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Therefore utilizing a dose escalation method that has toxicity based endpoints may not be as appropriate for determination of recommended dose, and alternative parameters such as pharmacokinetic or pharmacodynamic outcomes are potentially appealing options.
Alternative parameters such as the orientation ratio index [ 22], the FT image covariance matrix [ 23], the power spectral gradient [ 25] or the degree of FT eccentricity [ 27] were also used.
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Future studies should investigate alternative parameters that define bat community structure such as diet and abundance to better determine the influence of competition and prey defences on the structure of insectivorous bat ensembles in southern Africa.
Some alternative strategies to choose the BLUP|GA parameters, such as determining weights by variance component estimation, were tested but generally did not lead to improved performance, especially so with reference datasets of limited size (results not shown).
All other parameters, such as minimum coverage, minimum alternative allele frequency, and strand bias were the same between the two settings (parameter files provided).
A micromechanics-based approach may be more appropriate to model the local events such as "pull-out", where alternative parameters may emerge.
An alternative for phase II studies is to report parameters, such as time in hospital versus days at home, to describe the situation of the patients, and such factors are most likely important for the patients' QoL.
Flood management alternatives are often evaluated on the basis of flood parameters such as depth and velocity.
The proposed SER system provides a flexible alternative to column experiments and allows better control over system parameters such as pH, reaction time, and solid solution ratio.
Nonetheless, we did find strong relations between alternative parameters of adipose tissue dysfunction with EV-cystatin C levels, such as low-grade systemic inflammation and low HDL levels.
GDFTdyn may be an interesting alternative to classical GDFT strategies, which are based on flow parameters such as cardiac output or oxygen delivery.
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