Sentence examples for alternative fraction from inspiring English sources

However, current and future studies addressing alternative fraction size, total dose, overall treatment time and/or combination with chemotherapy or targeted agents may reveal regimens of equal or increased efficacy with reduced late morbidities.

An alternative fraction method of quantitation was also used to determine RAP stimulation by PT, calculated as the fraction of counts in bands 9 and above divided by the total sum of counts incorporated, normalized as described for the decay method.

The estimated sensitivity ranged from as high as 30% for pSNMs with alternative allele fraction 0.2 to as low as 1% for pSNMs with alternative allele fraction 0.4 (Supplementary information, Figure S3).

The sensitivity of pSNM detection in non-repetitive genomic regions depended on the alternative allele fraction.

Then some of the NA12891 reads were randomly replaced with the corresponding reads of NA12891 following a binomial sampling with given alternative allele fraction and read depth.

As shown in Figure 1C, our genotyper was able to detect a mosaic site whose alternative allele fraction was around 0.05-0.35 and 0.65-0.95 when the sequencing depth reached 80. Increasing sequencing depth could improve the power to distinguish between mosaic and heterozygous sites, whereas increasing base quality could be helpful in distinguishing between mosaic and homozygous sites.

These two sites had alternative allele fractions of ∼1/3 in both whole-genome sequencing and pyrosequencing data, consistent with the expected allele fraction when three copies of DNA were present.

Sites with alternative allele fractions 0 and 0.5 were considered homozygous for the reference allele and heterozygous, respectively.

By counting the allele numbers in the whole-genome sequencing data, we calculated the alternative allele fractions of the validated pSNMs, which range from 5%to31%1% (Table 2).

Sensitivity was calculated as the proportion of simulated pSNMs correctly identified as "mosaic" for each of the alternative allele fractions ranging from 0.05, 0.1, 0.2, 0.3, to 0.4 in non-repetitive regions.

In addition, two pSNMs whose alternative allele fractions did not exceed 5% by pyrosequencing showed a statistically significant difference between the case and three negative control samples (one-tailed Z-test, P-value < 2.2 × 10−16), and were thus also included in subsequent validation.