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During the last decades, several studies have proposed manganese (Mn) complexes as alternative contrast agents for magnetic resonance imaging (MRI).
Phase contrast X-ray generates images of the refraction of X-rays as they pass through a medium and therefore offers an alternative contrast mechanism.
Diffusion-weighted imaging (DWI) is an alternative contrast mechanism that has been shown to identify tissue changes during pre-clinical thermal treatments of canine prostate tumours [9, 10] and murine tumour models [11].
In the case of ionic crystals, an explanation based on short-range electrostatic forces due to the variations of the Madelung surface potential has been suggested, yet an induced polarization of the ions at the tip-surface interface due to the bias-voltage modulation applied in KPFM may be an alternative contrast mechanism [7].
Carbon dioxide-based venography is a promising alternative contrast choice for use in patients with advanced chronic kidney disease and ESRD [ 38].
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It is particularly useful in patients who tolerate gadolinium-based contrast agents where DW-MRI has the potential to be an alternative contrast-enhanced technique.
This contrast is also thought to provide greater sensitivity to a face-selective region in the anterior temporal lobe compared with alternative contrasts such as faces versus houses/places (Kriegeskorte et al. 2007; Rajimehr et al. 2009).
Model 3 showed the results corresponding to models 1 and 2 when variables from both the models were included in the same model, but with alternative contrasts for the hospitalized.
Intention to change was modelled to enable two alternative contrasts to be made: 'Intention to reduce use' vs. 'Having already reduced use', and 'Intention to reduce use' vs. 'No intention to reduce use'.
We constructed two alternative contrasts to measure the incremental burden of fatiguing illness: 1. CFS compared to NF, 2. ISF compared to NF. Comparisons between the CFS and NF groups may be thought as capturing the effects of alleviating all fatiguing symptoms.
However, the high toxicity of Gd3 + and potential side effects including nephrogenic systemic fibrosis have led to the search for alternative T1 contrast agents.
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