Sentence examples for alternative annotations from inspiring English sources
For probes lacking an annotation in TIGR5, several alternative annotations were considered either based on information provided by the manufacturer (Agilent) or on BLAST searches for the corresponding gene model in Arabidopsis.
Where metabolites share an identical bulk formula, multiple alternative annotations may be possible.
However, these permit alternative annotations of some variants and hence foster inconsistency.
Furthermore, CAVA flags any variant with potential alternative representations, outputting the alternative annotations as well.
Equally importantly, CAVA highlights indels that have possible alternative annotations so that fully informed clinical interpretation can be performed.
It is possible that these annotations contain different proportions of embryonically expressed genes and thus alternative annotations may be better for different tissues.
Therefore, complementary and/or alternative annotation methods are needed to overcome the aforementioned shortcomings of explicit tagging.
A good practice is to try alternative annotation groupings and measure their influence on the results.
An alternative approach is to predict multiple overlapping gene structures, or a single gene structure overlapping existing alternative annotation.
For the Geneatlas dataset, we used an alternative annotation and normalization scheme as described in the Methods section.
The results are consistent: only 3.5% of genes as defined using the alternative annotation were significant in all pre-processing schemes (P-value Wald test ≤ 0.05).
