Sentence examples for alternative alteration from inspiring English sources

Epigenetic gene silencing, particularly DNA hypermethylation, has been recognized as an alternative alteration besides mutations and deletions in the "two hits" inactivation of tumor suppressor genes.

Research on the pathogenesis of TREDs includes studies on toxic RNA that triggers alternative splicing alteration in numerous genes linked to the clinical symptoms of DM1 [ 12, 13], and studies on toxic poly-Q proteins that impair many cellular functions [ 11].

We searched for alternative molecular alterations responsible for c-MYC deregulation in these cases and observed an altered expression of a specific miRNA, hsa-mir-34b, predicted to regulate MYC [10].

Few studies so far examined alternative splicing alterations in blood cells of neurodegenerative disease patients, particularly Parkinson's disease (PD).

Finally, the relevance of the alternative splicing alterations we detect in the TnT and CG30084 genes is currently unknown.

Muscle defects are likely caused by alternative splicing alterations in muscle transcripts of which two have been recently described in muscleblind mutants [27], [28].

Regarding changes in alternative splicing, alterations in the 3' end but not in the 5' end of the mRNA were found.

Further studies are needed to determine if GH is directly inducing cellular senescence in WAT or if GH actions on other target organs or alternative downstream alterations in insulin-like growth factor-1, insulin or glucose levels are responsible.

In addition, most wild-type p53 types of cancer harbour alternative genetic alterations such as mutations in APC in colon cancer, BRCA1 and BRCA2 in breast cancer, and B-RAF in melanoma.

Methylation of gene regulatory elements is an epigenetic change representing an alternative to genetic alteration for gene inactivation.

The availability of many low-sodium alternatives makes alterations of food consumption patterns an essential strategy to reduce sodium intake.