We compare eight alternative measures of adherence, which we label CMA1-CMA8 (Table 1).
Simulated patients' characteristics matched those from a French observational study and the real-world adherence alternative employed persistence data from published database analysis.
GBTM offers researchers an alternative method of determining adherence to treatment, one that better captures dynamic changes in adherence over time.
Figure 2 shows that the use of alternative thresholds for dichotomising adherence changed to only a small extent the cost-effectiveness estimates associated with enhancing adherence from baseline to 80% (being the ICER values €52 000 and €68 000 for thresholds of 70%and90%0%, respectively).
If children show no improvement with one first-line treatment, despite adherence, an alternative therapy should be tried.
74 Alternative methods of assessing adherence to exercise-based rehabilitation do exist and include attendance at appointments, 75 although this does not necessarily mean the individual is completing the activities they are meant to be doing.
Such an analysis does not evaluate the exposure-disease relationship, but rather examines the impact of offering a new therapy versus an alternative therapy (regardless of adherence to the intervention, or control or placebo).
The overall aim of this evaluation was to ascertain the reliability of maternal verbal reports and weight measurements of unused returned nevirapine suspension as an alternative method of measuring adherence.
These comparative analyses are important because differences in cost of acquisition, efficacy, side effects, and therapeutic adherence between alternative treatments for AR could have a considerable impact on the control and in the tremendous economic burden of the disease.
Conceptually, inappropriate prescribing encompasses a range of behaviours for healthcare providers, including errors in prescribing, over-prescribing, under-prescribing, cost effectiveness, non-adherence and alternative therapies [ 5].
A recent review of published criteria has examined many aspects of inappropriate prescribing, including errors in prescribing, over-prescribing, under-prescribing, cost ineffectiveness, non-adherence and alternative therapies [ 5].
