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This alternation procedure was continued until the rats had pressed both levers at least 100 times in less than 20 min. Fixed consecutive number training was then begun.
Furthermore, the fornix lesion deficit was immediately reinstated by a spatial alternation procedure that excluded the use of intra-maze cues but not body turn cues (adjacent T-mazes, Experiment 7).
For example, in a continuous alternation procedure in a T-maze, in which the goal arms were connected to the start arm, complete bilateral hippocampal lesions had no effect on alternation performance.
In practice, it means that inpatients are screened on a daily basis and outpatients are screened following a sequential alternation procedure that guarantees an equal screening frequency of the six outpatient clinics involved in this study.
For example, in the OIC procedure originally described by Dix and Aggleton [5], animals received two exposures to each of the objects, A and B, in their respective contexts in a double alternation procedure (A, B, B, A); however in most OIC reports animals received only one preexposure to each of A and B [4,6 8,11,12,31].
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Alternation procedures in rodents are highly sensitive to manipulations of the hippocampus.
Previous attempts to develop alternation procedures that do not require human intervention have often resulted in a loss of hippocampal sensitivity.
In another study (Markowski et al. 2002), male and female offspring that were born to Holtzman rats that were exposed to 0.18 μg TCDD/kg were significantly less accurate in cued delayed alternation procedures that were used to examine operant behavior compared with the other two groups (control and 0.54 μg TCDD/kg).
This study was designed to examine the effects of early postnatal injection of PCP on later acquisition and performance of a delayed spatial alternation task, a procedure that is sensitive to manipulations of the prefrontal cortex.
Three experiments were designed to test the efficacy of ideation procedures that involved alternation of individual and group idea generation sessions (hybrid brainstorming) as compared to traditional individual and group ideation.
However, many versions of spontaneous alternation test regimes – regarding apparatus and procedure – have been described in the literature, some with alternation rates as high as 93% [e.g. [ 16]].
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