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Polyphenol treatment had no effect on the results to the spontaneous alternation paradigm: transgenic animals do not show any impairment for this task and behave similarly to the control animals.
The purpose of this study was to establish an automated rewarded alternation paradigm and test whether it was sensitive to hippocampal damage.
The acute effects of the highly selective dopamine D4 receptor antagonist L-745,870 on rats' performance in a spontaneous alternation paradigm in a T-maze were examined.
The results show that the neural substrate mediating the spatial distribution of responses in the spontaneous alternation paradigm includes the D4 receptor.
L-745,870 has also been found to have an effect on working memory in a delayed alternation paradigm, possibly via its effect on the prefrontal cortex [ 14].
Bilateral hippocampal-lesioned mice were assessed in the standard, hand-run, discrete-trial rewarded alternation paradigm and in the automated paradigm, according to a cross-over design.
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Alternation rates of 60 70% are usual in spontaneous alternation paradigms, depending on the behavioural strategy used by the rats [ 15].
Alternation paradigms in rodents are based on win-shift behaviour that may reflect foraging in the wild [6,7].
Spontaneous alternation paradigms model the natural tendency of rodents to spontaneously and flexibly shift between alternative spatial responses.
However, the behavioural strategy used by rats in some spontaneous alternation paradigms with very high alternation rates probably differs from the "standard" spontaneous alternation strategy.
In this respect, the performance of the vHPC rats on the classical, rewarded alternation T maze paradigm might be informative.
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