Alternatively, they could result in exon skipping, alternative splicing, or alternations in expression profiles if the corresponding P450 introns contain regulatory sequences as exemplified by the Mu insertion into an intron of the Knotted locus in Maize [ 67].
Differential expression analysis revealed 93 miRNAs (76 upregulated & 17 downregulated) that exhibited statistically significant alternations in expression between the fast and slow growing groups.
In humans, while some authors have not observed an alternation in MnSOD expression in endothelial progenitor cells with aging [ 55], others have demonstrated a decrease of this enzyme's expression in endothelial cells of sedentary aged subjects [ 56].
Notably, an alternation in Hox expression was shown to consequently allow for the emergence of novel, functional neuronal circuits [51].
When we compared the phenotype of progeny wild type for dCTCF but differing in their parental genotype, no significant alternation in garnet expression levels resulted between Dp(1 f LJ9MAT progeny from mothers carrying CTCF 30 and either of the external or internal controls wild type for dCTCF.
Possible alternations in the expression of two critical genes involved in yeast apoptosis, MCA1 and NUC1, were assayed by real-time PCR.
In conclusion, the current study revealed that insulin pathways, oxidative balance and glucose metabolism encoded genetic makeup are susceptible to MeHg toxicity and the subsequent oxidative stress and alternations in gene expression could lead toward functional abnormalities in other organs.
Comparable alternations in MARCKS expression were also observed in another mouse line, ICR (data not shown).
Quantitative PCR (qPCR) confirmed that no significant alternations in the expression levels of OCT3/4, SOX2 and NANOG transcripts among CM from different feeders (Fig. S3C).
Then the alternations in gene expression could possibly be used as diagnostic measures.
