The phrase "alternating nucleotide" is correct and usable in written English.
It can be used in contexts related to genetics, molecular biology, or discussions about DNA and RNA sequences where the pattern of nucleotides alternates.
Example: "The study focused on the effects of alternating nucleotide sequences on gene expression."
Alternatives: "interchanging nucleotide" or "switching nucleotide".
Each PCR reaction mixture contained five primers: two allele-specific primers, each one containing one of two different sequences at its 5'-end, and a 3'-part corresponding to the target sequence with alternating nucleotides at the 3'-end, a common reverse primer, and two fluorescently labeled Amplifluor® primers matching the 5'-portion of the allele-specific primers.
Black letters indicate the same nucleotide as SBW25, red letters indicate the same nucleotide as an SBW25 synonymous mutant and grey letters indicate an alternate nucleotide.
We next studied the effects of alternate nucleotide states on the motility of RNPs.
This was further confirmed in the subpopulation of 29 individuals bearing rare SNPs who, in the absence of heterozygous change at P25, presented significantly shorter stature in the heterozygous alternate nucleotide change at P6 (AG).
Mean height SDS comparison among these genotypes was not statistically significant, although mean height SDS of alternate nucleotide carriers at position 5178 (P12) tended to be shorter (Table 4).
Our results show that the GI 183148 homozygous sequence is present in our population except for SNP P14 in the 5′UTR region which is only present as the alternate nucleotide in homozygous or heterozygous states.
First, the authors stated that RP genes present paralogous copies, which have arisen through allopolyploidization. Second, they reported two alternate nucleotide stretches conserved within the 5' untranslated regions (UTR) of multiple ribosomal cDNAs and they suggested that these motifs are involved in the differential transcriptional regulation of paralogous RP genes.
20 A systematic SNP study was conducted by Adkins et al. 21 in GH1 promoter, coding and noncoding regions in DNAs from placental tissues, and analysis of associations between genotypes and birth weight revealed an association between an alternate nucleotide at −1 and +3 of translation initiation site and fetal growth restriction.
The potential for Z-DNA formation of alternating pyrimidine purine nucleotides [ CG) n> CA) n> TA n] correlates with frameshift potential (33).
Sequences as short as 8 bps of alternating purine pyrimidine nucleotides may form Z-DNA structures (Rich et al. 1984; Kim et al. 1996), and poly(A/T) sequences longer than 7 bp create uniformly bent DNA structures (Nadeau and Crothers 1989; Crothers et al. 1990).
