We predict that use of antisense ASOs in combination with small molecule therapeutics against the target protein encoded by the antisense-targeted mRNA, or an alternate target in the same or a connected biological pathway, will likely be the most beneficial application of this emerging class of therapeutic agent.
The law enforcement official also said the report may have prompted them to choose an alternate target.
"Sergeant," Mr. Cahill remembers him saying, "I can tell you what you had for breakfast in Italy this morning, I can tell who your briefing officer was and I can tell you what your alternate target was.
As head of a group working to find a way to get the Navy out, I found several uninhabited and accessible alternate target ranges, among them nearby Mona Island and Dog Island, all locations the Navy might shell to its heart's content.
When Binalshibh pressed Atta to retain the White House as a target during one of their communications in early August, Atta agreed but said he would hold the Capitol in reserve as an alternate target, in case the White House proved impossible.
In an interview posted Thursday on a reformist Web site, Mehdi Karroubi, a candidate in last summer's presidential election and former speaker of Parliament, seemed to be shifting the blame for the violent postelection crackdown away from Ayatollah Khamenei, offering an alternate target, Ayatollah Ahmad Jannati, a reactionary cleric who heads the influential Guardian Council.
An alternate target concept for RIA, the tilted slab approach promises to be simple with fast ion release and capable of withstanding high beam intensities while providing considerable yields via spallation.
As they attack began, the Ju 88s turned to West Malling, and began dive-bombing attacks as an alternate target.
The infamous Watergate break-in of the Democratic National Committee headquarters in June 1972 was an alternate target after bugging McGovern's headquarters was explored.
On 14 November 19 Stukas from III./St.G 1 with escort drawn from JG 26 and JG 51 went out against another convoy; as no targets were found over the estuary, the Stukas proceeded to attack Dover, their alternate target.
In the current study, switching the eye of presentation caused most areas that showed strong onset bias to be dominated by the alternate target.
