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They point to alternate mechanisms than those suggested by Keith and Padden.
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The lack of direct correlation of demethylation of promoter and increased expression in some of these targets (Figure 2) may simply be a reflection of the small cohort used to test this association in HNSCC, but may also be due to alternate mechanisms of transcriptional control of these genes other than promoter methylation status, including other promoters, repressors, or mediators (e.g. BORIS).
Thus, there are alternate mechanisms by which 5'AZA can cause demethylation other than by its incorporation into DNA during cell division.
"Stress, drugs, life-changing experiences, may all activate alternate mechanisms," said Dr Fisher.
Besides divergence, alternate mechanisms must exist to explain the rapid burst of MITEs in O. brachyantha.
"The trouble is that not only is Safe Harbor vulnerable to PRISM, so are the several alternate mechanisms for exporting data devised since".
Thus, alternate mechanisms of tumor suppressor gene inactivation may exist in the ESFT cell of origin.
Interestingly, viruses have evolved alternate mechanisms to subvert normal translational controls [13].
Alternate mechanisms for local procurement should be made.
Alternate mechanisms could involve phthalate impacts on endocrine function.
This dissimilarity may reflect alternate mechanisms of Polycomb-mediated silencing.
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