Sentence examples for altering translation from inspiring English sources

MiRNAs regulate gene expression at the post-transcriptional level by altering translation of target messenger RNAs (mRNAs) into proteins.

Or, they can cause a structural change in RNA, altering translation efficacy, and thereby, leading to a change in ESR1 gene expression rate [22].

Previously undertaken mutagenesis studies in yeast [70], [71] identified up to eight residues in eEF1A clustered within domains II and III, which (i) reduce actin disorganization induced by overexpression of eEF1A in yeast, (ii) inhibit actin-bundling without altering translation in vivo, and/or (iii) reduce actin-bundling.

While altering translation efficiency through manipulation of codon or codon pair usage may attenuate virus replication, other virus compositional features may additionally contribute to replication phenotypes.

Small regulatory RNAs (sRNAs) function as posttranscriptional regulators by altering translation or stability of the target mRNA, which increases their applicability in different physiological processes in bacteria [ 1].

Organisms display kinetic preference for certain codons sequences, and codon replacements can significantly affect the efficiency of translation elongation, thereby altering translation rates and total gene expression levels.

The proposed mechanism in which alterations in CP bias alter translation efficiency and it is this that inhibits virus replication introduces a conceptual model in which it is the virus that is intrinsically defective.

Alternatively, it may be that the tumors used in the current study are more "addicted" to altered translation initiation rates (due to increased numbers of altered signaling pathways or processes) than the Eμ-myc/PTEN tumors previously used [4], and hence respond to single agent treatment.

The simplest mechanism involves sRNA binding and occlusion of the RBS or start codon of a target mRNA [ 46] (Fig. 2A), however binding outside of this region can also alter translation [ 47– 48]. Figure 2A highlights several sRNA translational regulators and the natural genes they target such as IS10 RNA-OUT/RNA-IN [ 49], and sok/ hok [ 50].

The ways in which they may alter translation, however, are not well understood.

Spencer, P.S., Siller, E., Anderson, J.F. & Barral, J.M. Silent substitutions predictably alter translation elongation rates and protein folding efficiencies.