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Histones undergo posttranslational modifications altering their interaction with DNA and nuclear proteins and which remodel the chromatin condensation status and gene expression.
4 The three human SUMO proteins (SUMO-1, SUMO-2 and SUMO-3) are conjugated to diverse target proteins, thereby often altering their interaction with other proteins through interactions between SUMO and SUMO-binding motifs.
IGFBP-3 is the main binding protein of IGF-I, and it circulates in the plasma, prolonging the half-life of IGFs and altering their interaction with cell surface receptors (Hansel et al, 2004; Renehan et al, 2004).
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In our model, ABT-263, ABT-199 and ABT-737 bind Bcl-xL, Bcl-2 and Bcl-w and deactivate these cellular 'fuses' by altering their interactions with pro-apoptotic Bad, Bax and UACA in virus-infected cells.
Surfactant may directly compete with Mtb for the receptor binding site, or that aggregated mycobacteria alter their interaction with the host cells, as shown for SP-D [44], [45].
The method of transfection also altered their interaction.
These elements do not alter their interaction with the MT in the different nucleotide states calculated.
Mutations in proteins that cause syndromic ciliopathies with retinal degeneration are shown to alter their interaction with RPGR (22, 45).
Moreover, changes in the glycan structures associated with viral glycoproteins may also alter their interaction with C-type lectins and consequentially, inhibit pro-inflammatory cytokine production.
The N-terminal tails of these proteins undergo post-translational modifications including acetylation, deacetylation and methylation which alter their interaction with DNA and can thus impact gene expression.
These results suggested that PHD2 disruption in tumour cells altered their interaction with the tumour microenvironment, allowing for more efficient growth.
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