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The flexibility of the described design allows for sensor specificity change through altering the specificity of the aptamer.
Several groups reported success in altering the specificity of Type IIG REases.
(vi) Synthesis of a greater diversity of beneficial peptides by selection for mutations in the acceptor stem of tRNA, altering the specificity of aminoacylation.
In order to generate information that might be useful for altering the specificity of serine integrases and to improve their efficiency, we tested a hybridization strategy that has been successful with several small serine recombinases.
The T cell coreceptors CD8 and CD4 play a unique role in biology by assisting in the recognition of pMHCI and pMHCII antigens, respectively, without altering the specificity of TCR/pMHC interactions.
T cells play a key role in cell-mediated immunity and, recently, strategies to genetically modify T cells either through altering the specificity of the T cell receptor (TCR) or through introducing antibody-like recognition in chimeric antigen receptors (CARs) have made substantial advances.
Similar(54)
Modification in the structure of SAHA altered the specificity of 'δ ' towards a specific HDAC enzyme[83].
A PBP added to an in vitro assay altered the specificity of a moth pheromone receptor, making its response more specific [31].
A second series of reporters, activated by human rhinovirus 3C protease, demonstrated that we could alter the specificity of the reporter by reengineering the protease recognition sequence.
Variations in N-CAM activity thus do not occur by changes in the amino acid sequence that alter the specificity of binding.
Thus, the levQE170A/F292S mutations altered the specificity of the signaling complex independently of LevT.
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