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We also demonstrate that the "loop" regions of Bub1 and BubR1 impart very different behaviors to Bub3, and that they cannot be replaced without fundamentally altering the functions of these proteins, a quite striking manifestation of sub-functionalization.
Taken together, these findings confirm a role for oxidative regulation of inflammation by altering the functions of extracellular mediators such as alpha(2 M.
The growth in socioeconomic metabolism associated with industrialization is altering the functions of the biosphere, becoming the major drivers of global climate change.
By altering the functions of the cricket's central nervous system, the worm coerces it into jumping slap bang into the nearest body of water.
As members of the Gαq family are known to regulate mitogenic pathways [ 39], Fhit may exert its tumor suppressive effect by altering the functions of these Gα subunits.
Most drugs have beneficial as well as adverse effects and exert their biological functions by adjusting and altering the functions of their target proteins.
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Mutations, which are less common, often cause disease by altering the function of a key protein.
Climate change is shifting the phenological cycles of plants1, thereby altering the functioning of ecosystems, which in turn induces feedbacks to the climate system2.
To overcome the problems of low solubility and dimerization, subdomain interactions were engineered without altering the function of the protein.
Other startups have gotten in trouble by materially altering the function of a site's video player (i.e. Searchles pulling videos out of Grouper's player).
Patients who have low expression of the pro-apoptotic protein Bim or have polymorphisms altering the function of Bim have lower response to EGFR and ALK inhibitors [31].
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