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The trick is achieving "knock down" by altering the functioning of targeted proteins within a designated cell -- no trivial task.
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This concept allows re-configuration of the control without altering the function block diagram.
Other startups have gotten in trouble by materially altering the function of a site's video player (i.e. Searchles pulling videos out of Grouper's player).
To overcome the problems of low solubility and dimerization, subdomain interactions were engineered without altering the function of the protein.
The growth in socioeconomic metabolism associated with industrialization is altering the functions of the biosphere, becoming the major drivers of global climate change.
Biological research often focuses on altering the function(s) of a single selected protein.
How is Duo1-S115F altheing the function of the Dam1/DASH complex?
EVs are capable of altering the function of the recipient cells.
Other HPV proteins act indirectly by altering the function of cellular factors.
Among potential risk modifying factors are SNPs altering the function of MDM2, the murine double-minute 2 homolog.
Most drugs have beneficial as well as adverse effects and exert their biological functions by adjusting and altering the functions of their target proteins.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com