Sentence examples for altering the functionality of from inspiring English sources

The increased proliferative capacity of ER+ breast cancer cells subjected to mild nitrosative stress therefore arises through mechanisms altering the functionality of ERα and/or p53.

Disrupting the lipid rafts' integrity, which are plasma membrane microdomains rich in cholesterol, may modify tumorigenic processes by altering the functionality of CD44, which is a cell surface receptor involved in cell migration and tumor metastasis [ 150, 151].

As cell cycle abnormalities have been observed in ovarian cancer (Milde-Langosch and Riethdorf, 2003; De Meyer et al, 2009), we hypothesized that common genetic variation in genes altering the functionality of the molecules may influence the ovarian carcinogenic process.

These alterations may subsequently alter the functionality of the ASV as compared with the engineered or metalloprotease-generated soluble receptors.

Plasma surface modification is a versatile and economic surface-modification technique that alters the functionality of biomaterials.

In contrast, natural disasters are natural hazards that severely and negatively alter the functionality of the social environment or infrastructure (Alcántara-Ayala 2002 IPCCC 2012).

The interfacial coatings around lipid droplets can be tailored in a number of ways to alter the functionality of emulsion-based delivery systems.

While the functional output of the core product is identical across the products, product variety is created using add-on services that do not alter the functionality of the core product.

Furthermore, co-delivery of the GM-CSF DNA altered the functionality of HA-specific T cells but this effect markedly differed between the two compartments.

Another possibility would be that the observed changes in the protein-to-cardiolipin ratio alter the functionality of the respiratory chain and/or the assembly of respiratory complexes in R1H cells.

SNPs detected in this study presumably alter the functionality of the dopamine receptor D4 and its affinity to dopamine.