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This acidic extension and the Jun basic region form a heterodimeric coiled-coil structure that stabilizes the complex and prevents the basic region of Jun from binding to DNA, thereby titrating the functionally active AP-1 heterodimer concentration in the cell without altering the function of other B-ZIP proteins [24], [33].
Mutations, which are less common, often cause disease by altering the function of a key protein.
To overcome the problems of low solubility and dimerization, subdomain interactions were engineered without altering the function of the protein.
Carol Clark's The Prisoner seems to me to stay almost entirely clear of it, achieving a quite remarkable degree of fluency by means of no more than deft minor adjustments to the original syntax, altering the function of a clause here, dividing a sentence into two there.
Results are discussed in the context of verbal behavior altering the function of present conditions in subjects with limited verbal repertory, as well as in the context of new applications to make a difference in chronic behaviors.
In this review article, various developments that have taken place in the last decade with respect to identifying and altering the function of ripening-related genes have been described.
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Climate change is shifting the phenological cycles of plants1, thereby altering the functioning of ecosystems, which in turn induces feedbacks to the climate system2.
Taken together, these findings confirm a role for oxidative regulation of inflammation by altering the functions of extracellular mediators such as alpha(2 M.
The trick is achieving "knock down" by altering the functioning of targeted proteins within a designated cell -- no trivial task.
Shortly thereafter, mutations that altered the function of the sclerostin (SOST) gene were also associated with altered human bone mass.
These changes alter the function of the targeted gene facilitating the analysis of gene function.
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