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Phenothiazines may weaken lysosomes by altering the fluidity of their lipid membrane, making them more likely to rupture.
This prompted us to hypothesize that the multimerization of IFITM proteins inhibits viral fusion by altering the fluidity of the cell membrane.
Potential mechanisms have been proposed and include (1) a shift in the progesterone and oestradiol ratio compromising uterine activation [ 3], (2) cholesterol altering the fluidity of the plasma membrane effecting integral protein expression [ 3, 12] and possible utero-relaxant effects of adipokines and endocrine disruption resulting from increased white adipose tissue depots [ 3, 33– 33].
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Alternatively, the enrichment of EerI, a compound with a hydrophobic membrane binding moiety, in the ER membrane may alter the fluidity of the membrane to indirectly affect protein import into the ER.
Thus, the stable association of these two affinity-tagged proteins with LPS transport components suggests the possibility that they might cooperate with LPS proteins to mobilize phospholipids and alter the fluidity of the membrane by providing a mechanism to move LPS molecules into and/or across the OM barrier.
This carbon radical then attacks other -CH2- groups in lipid molecules, and creates a chain reaction that alters the fluidity and shape of the membrane.
In addition, incorporation of n-3 PUFAs into the cell membrane alters the fluidity, structure, and/or function of lipid rafts or caveolae.
Membrane cholesterol has also been shown to alter the fluidity and bending stiffness of RBCs [ 100, 101].
Acute alcohol exposure induces malformation and malfunction of placenta-yolk sac tissues in rodents, reducing the labyrinth zone in the placenta and altering the permeability and fluidity of the cell membrane.
These compounds are potentially harmful to cells, causing damage by inactivating proteins, breaking nucleic acid strands, and altering the lipids and fluidity of cell membranes.
They shift and change with the fluidity of the times.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com