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This pathway not only sheds light on CRF signaling by characterizing a novel, neuronal CRF initiated signaling pathway, but also reveals novel potential targets for altering the effects of CRF on a variety of behaviors.
SB-334867, a HCRTr1 antagonist, reduces DA neuron firing and attenuates both cocaine-induced elevations in tonic and phasic DA signaling by altering the effects of cocaine on DA uptake inhibition.
We were then able to compare differences in growth and fitness between ZDB564 and ZDB706 variants with and without the evolved gltA1 allele, and thereby test whether this citrate synthase mutation potentiated the evolution Cit+ by altering the effects of the citT actualizing mutation.
This interpretation is in line with studies showing that loss of M4 by targeted genetic deletion of M4 in D1 receptor-expressing cells enhances amphetamine-, cocande-, anD1-likeke DA receptors agonist-induced locomotor activity, without altering the effects of the D2-like DA receptors agonist quinpirole.
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The interaction may take place at presynaptic terminals, altering the release of neurotransmitter, or it may take place postsynaptically, altering the effect of neurotransmitter.
This reduced the significant associations to null, altering the effect estimates and widening the confidence intervals.
We will also consider effect modifiers not directly associated with prenatal alcohol use, but potentially altering the effect of PAE.
Neither nisoxetine nor fluoxetine altered the effects of caffeine.
However, the rain altered the effects of some tested household products, especially gasoline.
Overall, these results demonstrate that the presence of vegetation altered the effects of salinity on carbon equivalency in created wetlands.
Age-related physiological changes in distribution, metabolism, and elimination often alter the effects of pharmacotherapies in older adults.
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