The phrase "altering the chromatin" is correct and usable in written English.
It can be used in scientific or academic contexts, particularly in discussions related to genetics, molecular biology, or epigenetics.
Example: "The research focused on altering the chromatin to understand its effects on gene expression."
Alternatives: "modifying the chromatin" or "changing the chromatin structure".
I also discuss how these dynamics contribute to reshaping chromatin and, by altering the chromatin landscape, may affect the maintenance of epigenetic information.
Component genes of the SMARCC gene family are members of the SWI/SNF family of proteins, whose members display helicase and ATPase activities and which are thought to regulate transcription of certain genes by altering the chromatin structure around those genes.
In addition to altering the chromatin state directly, these specific histone "marks" further act to recruit other remodelers containing "reader" bromodomains and tandem plant homeodomain (PHD) fingers (Taverna et al., 2007).
The HOTAIR noncoding RNA represses transcription in trans across 40 kb of the HOXD locus by altering the chromatin modifications through enhancement of the PCR2 activity at the HOXD locus [13].
We show here that the B-WICH core, the WSTF-SNF2h-NM1 proteiss, is required for altering the chromatin structure at the rDNA promoter and thereby allowing transcription to occur.
Our studies highlight the concept that specific subsets of H3K9 trimethylated regions exist across the genome and support a specific role for SETDB1 in altering the chromatin structure of zinc finger transcription factor genes through H3K9 methylation.
Epigenetic regulation of gene expression occurs due to alterations in chromatin proteins that do not change DNA sequence, but alter the chromatin architecture and the accessibility of genes, resulting in changes to gene expression that are preserved during cell division.
Introduction: The histone deacetylase (HDAC) inhibitors are a heterogeneous group of compounds that alter the chromatin structure of neoplastic cells, causing cell-cycle arrest, redifferentiation, and apoptosis.
Multiple factors, among which we have identified decreased Sp1 binding, a local decrease in acetylation activity, and enhanced synthesis and recruitment of a repressor histone demethylase, alter the chromatin configuration over the promoter, ultimately blocking its activation by c-jun.
DSBs alter the chromatin structures and induce rapid intermolecular phosphorylation of Atm on Ser1981, leading to dissociation of the previously inert dimer complex and activation of Atm.
Moreover, sperm capacitation could alter the chromatin stability, enhance remodeling asynchrony and result in delayed pronuclei formation and DNA synthesis [41], [42].
