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The design principle was based on the hypothesis that the deuterium substitution may reduce the rate of defluorination initiated by cleavage of the C H bond without altering the binding affinity for PBR.
Together, these results demonstrate that cyclotraxin-B selectively interacts with TrkB without altering the binding of BDNF.
This suggests that CIE-induced DNA demethylation may influence NR2B expression by altering the binding of these transcription factors.
Since the interaction of Fab AbD1564 with BMPR-IA is not affected by the mutation Q86A (Fig. 6C) a global misfolding altering the binding properties of the BMPR-IA variant can be ruled out.
Several mutations altering the binding site at the ribosome have been found [ 3, 21].
All these evidences strongly imply that rs10954213 regulates SLE by altering the binding of IRF5 mRNA and miR-181a.
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It has been shown that GAGs can alter the binding with selectins because the latter bind several glycoproteins [ 53].
FcγIIa and FcγIIIa possess polymorphisms that alter the binding of natural IgGs to those receptors.
Substituting SRC-1 with Adnectin-1 does not alter the binding conformation of Compound-1 in the ligand binding pocket.
As opposed to heparin, LMWLs significantly alter the binding of the active site fluorescent ligand p-aminobenzamidine.
The variation in the concentration of the precipitating agent did not alter the binding energy values of Zn 2p. Figure 5 N2 adorption-desoption isotherms (left) and XPS spectra of Zn 2p (right) for Z 1 to Z 8 samples.
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