Sentence examples for altering the affinity from inspiring English sources
Thus, the K-tail's role in the mechanochemical cycle might be more complex than simply altering the affinity for microtubules.
ISRIB could be altering the affinity of phospho-eIF2α for eIF2B or overcoming the nonproductive interaction that blocks GTP loading, mimicking the effect of these mutations.
Promising research has shown that allosteric modulators of GPCRs can be used to treat addiction by altering the affinity of the GPCR to its ligand or impacting its downstream signaling responses [ 72].
Therefore, the results obtained in this study provide support for the hypothesis that H2O2-induced methionine oxidation results in global and/or localized conformational changes that contribute to CN inactivation, by impairing the interaction between CNA and CNB, Ca2+ and CNB, or/and CaM and CNA, or/and by altering the affinity between AI and the catalytic center.
In humans, the Ca Pb interaction could arise in several ways, including binding of Pb to Ca or its derivatives in the gastrointestinal tract so that it is not available for absorption, competing with Pb in the gastrointestinal tract for transport sites and absorptive mechanisms, and altering the affinity of target tissues for Pb (Barltrop and Khoo 1975).
Therefore, the exchange of phenylalanine to another aromatic amino acid only slightly affects binding by reducing the affinity to phospholipids but not altering the affinity for galactolipids, whereas removal of the aromatic amino acid at this position significantly enhances affinity for galactolipids without significant alterations of the affinity for phospholipids.
This indicates a clear difference in proteins involved in the basal electron transfer mechanisms in the two different cell-types of a diazotrophic culture of N. punctiforme, consequently altering the affinities associated with electron uptake and release within the vegetative cells and heterocysts.
Thus, the chemical modifications (the addition of a spacer, a chelator and Ga) did not alter the affinity of R824 to its target, i.e. the PS.
The results showed that the modification of the aptamer does not significantly alter the affinity of the aptamer for the antibiotic.
In vitro experiments also showed that artificial envelopment of Ad completely altered the affinity towards both human and murine red blood cells.
The affinity studies of our labelled conjugated peptide showed that the adding of a spacer and of a chelating group in the Peptide N-terminus side did not alter the affinity and binding of R824 to its target.
